ABSTRACT
Objective To study the application effect of bandage corneal contact lens in ptosis during surgical treatment.Methods A total of 62 patients(73 eyes) with primary congenital ptosis in the First People's Hospital of Xiantao from March 2013 to March 2016 were randomly divided into group A,group B and group C.All of the three groups were treated by shortening levator palpebrae superioris muscle.The A group[20 cases(24 eyes)] began to wear bandage corneal contact lens during the operation.The B group [22 cases (25 eyes)] began to wear bandage corneal contact lens at the end of surgery.And the C group [20 cases (24 eyes)] took conventional methods for covering operative eyes.Postoperative follow-up lasted for 3 months,the postoperative FL staining scores and ocular pain severity were compared among the three groups.Results Comparison of postoperative FL staining scores:there was no statistically significant difference between B group and C group at postoperative 1 day(q =0.537,P ＞ 0.05),but the differences between B group and A group were statistically significant (q =10.876,11.298,all P ＜ 0.05),the differences among the three groups were statistically significant at the 7th day after surgery (q =8.682,4.048,4.722,all P ＜ 0.05).There was no statistically significant difference between B group and A group at postoperative 2 weeks (q =1.635,P ＞ 0.05),but the differences between group A/B and group C were statistically significant (q =8.747,7.201,all P ＜ 0.05).There were no statistically significant differences among the three groups at postoperative 3 months (q =1.607,0.186,1.438,all P ＞ 0.05).Comparison of postoperative ocular pain severity:there were no statistically significant differences among the three groups at postoperative 1 day (q =0.986,0.586,0.410,all P ＞ 0.05).At postoperative 7 days,there was no statistically significant difference between A group and B group (q =0.948,P ＞ 0.05),but the differences between A/B group and C group were statistically significant (q =4.743,3.843,all P ＜ 0.05).There were no statistically significant differences among the three groups at postoperative 1 month (q =3.181,0.599,2.654,all P ＞ 0.05).Postoperative upper eyelid radian and double eyelid plasty in all of 62 cases(73 eyes) was satisfied and the width of palpebral fissure when look straight was normal and locating above superior margin of pupil,but there were 16 eyes with slightly hypophasis which were all naturally closed good after 1 to 2 months without surgical incision infection and corneal infection.Conclusion It is effective to protect the cornea since intraoperative application of bandage corneal contact lens,and it with high safety to wear corneal contact lens shortly after surgery,which can promote corneal epithelial wound healing,reducing incidence of exposure keratitis,at the same time,it can obviously relieve ocular pain in patients.
ABSTRACT
Objective To compare efficacy of small incision cataract surgery whether combined with nucleus chopping or not in the treatment of cataract. Methods From March 2014 to September 2015,125 cases of age-related cataract(146 eyes) in the the First People′s Hospital of Xiantao were divided into 60 cases(75 eyes) of observation group and 65 cases(71 eyes) of control group by method of random sampling. The observation group accepted small incision cataract surgery combined with chopping nucleus. The control group only underwent small incision cataract surgery. The postoperative visual acuity,corneal astigmatism and operation time,and complications and so on in the two groups were compared. Results There was statistically significant difference in postoperative visual acuity after 1 week between the two groups(Z = -2. 078,P <0. 05),but there was no statistically significant difference in postoperative visual acuity after 1 month or 3 months between the two groups(Z= -0. 960,-0. 743,all P>0. 05). The postoperative corneal astigmatism after 1 week or 1 month between the observation group and the control group had statistically significant differences[(1. 33 ± 0. 45) D vs. (1. 52 ± 0. 49) D,(1. 03 ± 0. 42) D vs. (1. 18 ± 0. 44)D,t=2. 442,2. 108,all P<0. 05)],but there was no statistically significant difference in postoperative corneal astigmatism after 3 months between the two groups(t =0. 432,P >0. 05). There was no statistically significant difference in the operation time between the observation group and the control group[(11. 28 ± 2. 32) min vs. (11. 87 ± 2. 52)min,t=1. 473,P>0. 05]. One case of posterior capsular rupture occurred in the two groups,respec-tively. But serious complications such as lens nucleus escaped into vitreous cavity, explosive haemorrhage from the choroid or corneal endothelial decompensated had not been found. Conclusion The small incision cataract surgery combined with nucleus chopping has advantages in acquiring fast visual rehabilitation acuity in the early stage after operation,lower corneal astigmatism compared to that without nucleus chopping. Therefore,the small incision cataract surgery combined with nucleus chopping is worthy of clinical popularization and application.
ABSTRACT
Objective] By detecting the peripheral blood lymphocyte subsets of AML patients before and after taking cyclosporin A, preliminary discussion on making two hours effects of cyclosporin A on lymphocyte subsets in the body. [Methods] Fasting and taking cyclosporin A two hours of the expression of peripheral blood T, B lymphocytes and NK cel were detected by flow cytometry in 43 cases of patients with AML after transplantation. At the same time, application of chemiluminescence detection concentration of cyclosporin A. [Results] The results of cyclosporin A concentration: Fasting group is 125.43 ±65.94 ng·ml-1. Taking two hours group is 564.46 ±258.67 ng·ml-1; Taking two hours group compared with the fasting group, CD3+ cel is significantly reduced and NK cel is significantly increased, but CD4+, CD8+, CD19+cel and CD4+/CD8+ have no obvious change. [Conclusions] Taking cyclosporin A 2 hours can achieve distribution and affect the number of CD3+ cel in the body, but can not affect the B cel . To AML patients after transplantation, in order to achieve the appropriate concentration and keep abreast of the body's immune status of patients, it is necessary to monitor the concentration of cyclosporin A and lymphocyte subsets during their taking cyclosporin A, which helps us determine the prognosis.
ABSTRACT
[Objective] To investigate the changes of CD4+CD25+Foxp3+regulatory T cells (Tregs) in peripheral blood of patients with esophageal carcinoma and its possible clinical significance.[Methods] The flow cytometry was used to evaluate the population of CD4+,CD25+,Foxp3+T cells in the peripheral blood of the patients with esophageal carcinoma before therapy and of the healthy donors.[Results] The percentage of CD4+,CD25+,Foxp3+T cells of the esophageal carcinoma group before therapy was significantly higher than the healthy donors group (P